The companies said that the deal was made with server security in mind.
Third Brigade specialises in datacentre security and Trend hopes that the deal will bolster its arsenal in both the physical and virtualised server markets.
"Trend Micro has been a pioneer and global leader in server protection software for over ten years," said Trend chief executive Eva Chen.
"This acquisition underscores our commitment to maintaining that leadership position, and accelerates our ongoing efforts to deliver innovative new solutions that are uniquely suited to dynamic datacentres, as they expand from physical to virtual and public/private cloud-computing environments."
The company said that it also hopes to parlay Third Brigade's intrusion prevention systems (IPS) into its own enterprise offerings.
The two companies have previously had a deal which includes embedding the Third Brigade IPS in Trend Micro's Intrusion Defense Firewall product.
The two companies said that they hope to finalise the deal by the end of June.
Trend Micro buys Third Brigade
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